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Updated: Feb 11, 2026

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与选择性血清素再吸收抑制剂 (SSRI) 相关的男性性功能障碍:对FAERS数据的药监测不成比例性分析
Shouying Li1, Jiaxin Feng2, Shilin Zhang2
1Department of Urology, The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, Foshan 528000, China; Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Journal of affective disorders
|February 9, 2026
概括
选择性血清素再吸收抑制剂 (SSRI) 与男性性功能障碍有关,包括勃起功能障碍. 在FDA不良事件报告系统 (FAERS) 中报告变化突出了临床意识的必要性.
科学领域:
- 药物监督 药物监督 药物监督
- 神经科学是一个神经科学.
- 临床药理学 临床药理学
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 广泛用于治疗抑郁症.
- 男性性功能障碍是SSRI的潜在不良影响.
- 了解SSRI相关性性功能障碍的报告模式对于患者护理至关重要.
研究的目的:
- 为了比较与六种常见的SSRI相关的男性性功能障碍的报告模式和信号强度.
- 分析来自FDA不良事件报告系统 (FAERS) 的SSRI相关性性功能障碍数据.
主要方法:
- 从FAERS (2004-2025) 获取了西丁,帕洛克塞丁,塞特拉林,克萨明,利和利的不良事件数据.
- 使用报告几率比率 (ROR) 和比例报告比率 (PRR) 进行了不成比例分析.
- 识别了男性性功能障碍的潜在信号作为不良药物事件.
主要成果:
- 分析了6,631,746份SSRI药物不良事件报告.
- 在所有分析的SSRI中检测到男性性功能障碍,包括勃起功能障碍的显著不成比例信号.
- 勃起功能障碍和性功能障碍是常见的,在不同的SSRI中信号强度各不相同.
结论:
- FAERS分析显示,与SSRI相关的男性性功能障碍有显著信号.
- 观察到的信号变化可能反映了报告差异,而不是由于数据库限制而导致的比较风险.
- 这些发现强调了临床警和进一步研究SSRI诱导的性功能障碍的重要性.
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