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累积的糖尿病相关的代谢负担和听力损失的风险:一个基于人口的研究

Youngji Han¹, Kyu-Yup Lee², Incheol Seo³

¹Bio-Medical Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea.

Experimental gerontology

|February 9, 2026

概括

2型糖尿病并发症显著增加听力损失的风险. 管理微血管问题对于保护糖尿病患者的听力至关重要.

科学领域:

内分泌学在内分泌学.
耳鼻喉科耳鼻喉科耳鼻喉科
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

2型糖尿病 (T2DM) 与各种器官的微血管损伤有关.
对于T2DM微血管并发症的累积负担与感官衰退,特别是听力损失之间的关系,尚不清楚.

研究的目的:

调查糖尿病相关的微血管并发症与听力损失的发病率在一个大型基于人口的队列之间的关联.
确定微血管并发症的数量是否会改变T2DM患者听力损失的风险.

主要方法:

分析了493,272名英国生物库参与者 (43,332名T2DM患者) 的基于人口的队列研究.
使用ICD-10代码识别了与糖尿病相关的微血管并发症 (脏病,视网膜病,神经病).
听力损失发生率通过医院记录,死亡登记册和自我报告来确定.

主要成果:

与没有糖尿病的人相比,患有T2DM的参与者有更高的听力损失风险.
听力损失的风险随着微血管并发症的数量逐步增加 (1.28对于没有并发症的T2DM,1.83对于一个,和2.13对于两个或更多).
年轻人 (<60岁),HbA1c ≥6.5%的患者和胰岛素使用者中,相关性更明显.

结论:

在T2DM中,微血管并发症的累积负担独立地与听力损失的风险增加有关.
在全面的糖尿病护理中应考虑审计评估,特别是在多种并发症或血糖控制不佳的患者中.
功能障碍和全身炎症可能部分调解T2DM并发症和听力损失之间的关系.

关键词:

听力损失听力损失炎症炎症是一种炎症.微血管并发症微血管并发症腎病症是指腎病的疾病.神经病变是一种神经病变.视网膜病变是一种视网膜病变.2 型糖尿病 2 型糖尿病

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