常见的多模式神经成像机制注意力缺陷多动障碍和睡眠启动困难在发育中的大脑
Yujuan Zu1, Tao Pang2, Lingxue Luo2
1Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China; Henan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang Medical University, Xinxiang, China.
注意缺陷多动性障碍 (ADHD) 和睡眠启动困难 (SID) 具有共同的神经影像标记,特别是在大脑网络连接和白质道中. 这些标记物有助于解释ADHD症状与睡眠问题之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 注意缺陷多动症 (ADHD) 是一种常见的神经发育障碍.
- 睡眠障碍,特别是睡眠开始困难 (SID),影响20-55%的ADHD患者.
- 导致ADHD和SID并发症的神经成像机制尚不清楚.
研究的目的:
- 为了确定ADHD和SID的常见神经影像标记.
- 研究这些标记物如何调解ADHD和SID之间的关系.
- 为了在不同的ADHD发育轨迹中分析这些标记.
主要方法:
- 利用了ABCD研究中的多式神经成像数据和ADHD/SID表型 (n=11,868).
- 采用线性回归来找到共享的神经成像标记.
- 用于ADHD轨迹的潜在类增长分析 (LCGA) 和纵向分析的RI-CLPM.
主要成果:
- 确定了一些共同的标记物,包括DMN-DAN连接,皮质-状-体皮质电路 (右轨道前皮层体积) 和白质通道.
- 发现这些标记物能够调解ADHD和SID之间的关系.
- 三种不同的ADHD轨迹显示了与神经成像特征的不同关联,以及ADHD和SID之间的滞后效应.
结论:
- 常见的神经基质是ADHD和SID共同病变的基础.
- 这些基质调解ADHD症状对SID的影响.
- 独特的ADHD轨迹表现出神经成像协会的独特模式和与SID的纵向关系.
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