脉冲波形和电流方向改变网络层面的TMS诱导的功能连接:来自TMS-EEG的证据
Delia Lucarelli1, Giacomo Guidali2, Roberto Guidotti1
1Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies, G. D'Annunzio University of Chieti-Pescara, Chieti, Italy.
NeuroImage
|February 9, 2026
概括
跨磁刺激 (TMS) 参数显著改变运动系统中的电脑电图 (EEG) 功能连接. 了解这些影响对于优化TMS应用程序和解释网络动态至关重要.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 信号处理 信号处理
背景情况:
- 在同步跨磁刺激 (TMS) 期间对脑电图 (EEG) 数据的功能连接性分析为大脑网络动态提供了洞察力.
- 对于TMS参数对这些连接测量的特定影响还不太清楚,这限制了精确的应用.
研究的目的:
- 研究TMS脉冲波形和电流方向对电脑脑电图功能连接在电机系统中的影响.
- 分析这些效应在阿尔法和β频段.
主要方法:
- 使用开放访问存储库对32名健康参与者的EEG数据进行分析.
- 用不同的单相和双相脉冲波形和后向前 (PA) 和前向后 (AP) 电流方向刺激左主运动皮层 (M1).
- 在不同刺激条件下检查TMS诱导的功能连接模式.
主要成果:
- 阿尔法频段连接显示了广泛的,右侧的传感器运动区域的通信,独立于TMS参数.
- 贝塔频段连接更局部化,并且取决于条件.
- 与双相脉冲相比,单相脉冲增加了α波段连接,而AP电流导致了最大的调制.
- 特定的双相刺激模式 (PA-AP与AP-PA) 差异调节的α和β频段连接.
结论:
- TMS参数显著调节电机系统振荡动态和功能连接.
- 选择TMS功能可以选择性地激活不同的功能网络,从而导致TMS应用程序的变化.
- 这些发现强调了选择适当的TMS参数的重要性,并证实了电机系统通信中的频率特定模式.
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