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精密制药:生物信息学和药物基因组学作为个性化药物治疗的催化剂

Jaskaran Preet Singh Saini¹, Ankita Thakur¹, Deepak Yadav¹

¹Chitkara University School of Pharmacy, Chitkara University-Himachal Pradesh, HIMUDA Education Hub-Atal Shiksha Kunj, Solan, Himachal Pradesh 174103, India.

The Journal of pharmacy and pharmacology

|February 9, 2026

概括

生物信息学的进步正在彻底改变药物基因组学,通过预测药物反应来实现个性化医疗. 这有助于将遗传数据纳入临床实践,以获得更安全,更有效的治疗方法.

科学领域:

生物信息学是一种生物信息学.
药物基因组学药物基因组学
计算生物学计算生物学

背景情况:

药物基因组学将遗传信息与药物作用相结合.
生物信息学工具对于分析复杂的基因组数据至关重要.
个性化医疗旨在为个体患者量身定制治疗.

研究的目的:

审查生物信息学的进步如何改变药物基因组学.
突出数据库,计算工具和人工智能用于个性化医疗.
为了说明药物基因组数据在临床实践中的整合.

主要方法:

综合来自药物基因组学研究的证据.
使用像PharmGKB.B.这样的集中资源.
使用in silico预测工具 (例如PolyPhen,SIFT).

主要成果:

药物基因组应用表明,在各种领域,疗效提高,不良影响减少.
人工智能和机器学习增强了对高维度药物基因组数据的解释.
挑战包括计算复杂性,数据隐私和人口代表性不足.

结论:

生物信息学是个性化治疗药物基因组学操作的关键.
解决技术,伦理和公平挑战对于实现药物基因组学潜力至关重要.
推进精确医疗保健需要强大的变体解释和数据集成.

关键词:

医药公司GKBB 聚烯 (PolyPhen) 是一种聚烯.在 SIFT 系统中,生物信息学是一种生物信息学.个性化医疗是个性化的医疗.药物基因组学药物基因组学

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