地中海饮食的坚持与降低代谢功能障碍相关的脂肪性肝病中的肝纤维化风险有关
Meng-Lun Hsieh1,2, Tung-Hung Su3,4, Ying-Cheng Lin1,5
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
对地中海饮食 (MD) 的更高坚持与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的肝纤维化风险降低有关. 这支持MD作为肝脏健康的关键生活方式干预措施.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 众所周知,地中海饮食 (MD) 有助于肝硬化.
- 在MASLD患者中,MD粘附对肝纤维化的影响需要进一步调查.
研究的目的:
- 评估遵守地中海饮食 (MD) 与肝纤维化风险之间的关联.
- 为了研究在被诊断患有MASLD的人群中这种关系.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2017-2020) 的横截面分析.
- 使用振动控制的瞬态弹性学来识别MASLD.
- 替代地中海饮食 (aMED) 评分用于量化饮食坚持.
主要成果:
- 在MASLD患者中,较高的MD坚持 (高aMED组) 与显著肝纤维化风险显著降低相关 (OR=0.662).
- 在对心脏代谢风险因素和体力活动进行调整后,观察到这种保护作用.
- 敏感性分析表明,随着心脏代谢负担的增加,保护性关联会减弱.
结论:
- 增加对地中海饮食 (MD) 的坚持与MASLD患者显著肝纤维化风险降低有关.
- 医学医学是为减轻这种患者群体肝纤维化风险而推的一种生活方式干预措施.
- 进一步的研究可能会探索心脏代谢风险因素与MD益处之间的相互作用.
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