腹腔注意网络连接性将放射性隔离综合征与多发性硬化症区分开来:一项纵向静止状态fMRI研究
María Díez-Cirarda1, Jordi A Matías-Guiu1, Mariano Ruiz-Ortiz1
1From the Departments of Neurology (M.D.-C., J.A.M.-G.,C.C., J.M.-G., P.M.-E.), Radiology (L.G.-M., M.Y.-F.), Hospital Universitario Clínico San Carlos. Health Research Institute "San Carlos" (IdISCC), Madrid, Spain; Department of Medicine (J.A.M.-G., J.M.-G., P.M.-E., J.B.-L.), Departamento de Psicobiología y Metodología en Ciencias del Comportamiento (H.M.), Faculty of Psychology, Complutense University of Madrid, Madrid, Spain; Department of Neurology (M.R.-O.,A.D.-S., V.G.S.-S., A.L.-F., A.G.-L., P.S.-C., J.B.-L.), Hospital Universitario 12 de Octubre Research Institute (imas12) (M.R.-O., J.B.-L.), Madrid, Spain; Department of Neurology (Y.A.), Getafe University Hospital, Madrid, Spain; Faculty of Biomedical and Health Sciences (Y.A.), European University of Madrid, Villaciosa de Odón (Madrid), Spain; Department of Neurology (L.C.-F., E.M., S.S.M.), Hospital Universitario Ramón y Cajal, Red Española de Esclerosis Múltiple (REEM), Red de Enfermedades Inflamatorias (REI), Madrid, Spain; Department of Medicine (E.M.), University of Alcalá de Henares, Neurology (L.A.-P.), Príncipe de Asturias University, Alcalá de Henares (Madrid), Spain; Department of Neurology (M.L.M.-G.), Gregorio Marañón General University Hospital, Madrid, Spain; Medical Image Analysis Laboratory (LAIMBIO) (N.M.), Rey Juan Carlos University, Móstoles, Madrid, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) (J.B.-L.), Madrid, Spain.
放射性隔离综合征 (RIS) 和多发性硬化症 (MS) 随着时间的推移显示出不同的大脑连接变化. 腹部注意网络 (VAN) 的这些变化与疲劳水平相关,为早期MS检测提供了潜在的新生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医学研究 医学研究
背景情况:
- 放射性隔离综合征 (RIS) 呈现出偶尔的多发性硬化症 (MS) 类型的MRI病变.
- 纵向静止状态fMRI研究缺乏理解RIS中的大脑症状联系.
研究的目的:
- 为了比较临床,神经心理和静止状态功能连接 (FC) 轨迹在RIS,MS和健康对照 (HC) 中超过14个月.
- 调查FC变化与疲劳之间的关系.
- 确定潜在的生物标志物,以区分RIS和MS.
主要方法:
- 19名RIS,20名MS和22名HC接受了基线和14个月后的评估,包括疲劳,神经心理学和3TMRI (rs-fMRI,3D T1,FLAIR).
- 在正规网络中分析了FC,并使用了腹部注意网络 (VAN) 的种子到声分析.
- 统计分析包括重复测量ANOVA,FC-疲劳关系的回归,以及歧视的ROC曲线.
主要成果:
- 疲劳在RIS中保持稳定,但在MS中增加.
- 观察到对立的VAN连接轨迹:RIS显示VAN内部连接增加,而MS显示VAN内部连接减少.
- 在VAN连接的变化预测疲劳减少,和一个复合的VAN度量与MS高精度区分RIS (AUC=0.919).
结论:
- RIS和MS表现出不同的,以VAN为中心的FC轨迹,并行于它们不同的疲劳演变.
- 来自VAN的纵向FC指标可以作为早期MS检测的敏感,非侵入性生物标志物,补充传统的病变成像.
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