头发中的合成大麻素:LC-MS/MS的最新发现和分析方法的综述
Rafaela S Pereira1, Olívia B O Moreira2, Marcone Augusto L de Oliveira2
1Laboratório de Cromatografia, Department of Analytical Chemistry, Chemistry Institute, Universidade Federal Fluminense (Fluminense Federal University) - UFF, Brazil.
Analytica chimica acta
|February 9, 2026
概括
液体染色学-并联质谱学 (LC-MS/MS) 对于检测头发中的合成大麻素 (SCs) 是至关重要的,为慢性药物滥用提供了洞察力. 方法学的进步对于准确的毒理学分析和法医应用至关重要.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 合成大麻素 (SCs) 是一种强大的新型精神活性物质 (NPS),由于其多样性和非法市场的流行,它们对公共健康构成风险.
- 在SC检测方面的挑战来自于持续的结构修改,复杂的监管和毒理学评估.
- 头发分析为检测慢性接触滥用物质提供了一个扩展的窗口.
研究的目的:
- 批判性地审查液体染色学与质谱学 (LC-MS/MS) 结合的应用,以确定头发样本中的SCs.
- 评估必要的头发样本制备技术,并讨论质谱方法.
- 提供关于SC的最新概述,包括名称和毒理影响.
主要方法:
- 专注于LC-MS/MS方法论,用于在头发中确定SC.
- 深入评估头发样本的准备:收集,细分,消毒,粉碎和提取.
- 讨论低分辨率和高分辨率质谱学的优点和局限性.
主要成果:
- 详细介绍样品制备和用于头发SC分析的仪器参数的综合表.
- 对LC-MS/MS方法的评估,涵盖2013年至2025年的研究.
- 确定用于SC确定的主要方法参数.
结论:
- LC-MS/MS是检测头发中的SC的宝贵工具,有助于法医毒理学.
- 持续的方法进步是必要的,以提高SC确定精度.
- 改进的分析方法将支持更好的毒理学解释和对SC使用的法医洞察力.
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