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EZH2 的保存的 N-终端 SANT1 结合域 (SBD) 调节 PRC2 活动

Agata L Patriotis1, Douglas W Barrows2, Yadira Soto-Feliciano3,4

  • 1Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA; alpat@mit.edu.

Genes & development
|February 9, 2026
PubMed
概括

EZH2的SANT1结合域 (SBD) 对于Polycomb抑制复合体2 (PRC2) 甲基转移酶活性和全基因组H3K27甲基化至关重要. 它的删除抑制了癌细胞的生长,即使有EZH2功能增益突变.

关键词:
H3K27me3 在线阅读在 PRC2 中,PRC2 是 PRC2 的第一个类型.多重复合的多重复合.在这种情况下,染色染色素表观遗传学是指表观遗传学.

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