在晚期口腔粘膜黑色素瘤中使用Pembrolizumab与Anlotinib:一个回顾性试验
Yun Bi1,2,3, Xinwei Yang1,2,3, Yusheng Lu2,3
1School of Stomatology, Shandong Second Medical University, Weifang, China.
Oral diseases
|February 9, 2026
概括
布罗利祖马布和安洛丁尼布的组合在治疗晚期口腔粘膜黑色素瘤 (OMM) 中显示出潜在的疗效,副作用可控. 需要进一步的研究来证实OMM患者的这些发现.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 医学研究 医学研究
背景情况:
- 口腔粘膜黑色素瘤 (OMM) 是一种罕见且具有攻击性的癌症.
- 与其他黑色素瘤亚型相比,编程细胞死亡蛋白1 (PD-1) 单疗法在OMM中表现出有限的疗效.
研究的目的:
- 评估结合pembrolizumab与anlotinib在晚期OMM患者中的疗效和安全性.
- 评估客观反应率 (ORR),疾病控制率 (DCR),反应持续时间 (DOR),无进展生存率 (PFS),总生存率 (OS) 和与治疗相关的不良事件 (TRAEs).
主要方法:
- 在2018年8月至2024年9月期间治疗的41名晚期OMM患者的回顾性分析.
- 主要终点:客观反应率 (ORR).
- 二级终点:DCR,DOR,PFS,OS和TRAEs. 这些终点包括:
主要成果:
- 在17名患者中观察到41.4%的客观应答率 (ORR).
- 无进展生存时间 (PFS) 中位数为6.4个月;总生存时间 (OS) 中位数为10.0个月.
- 80.5%的患者经历了与治疗相关的不良事件 (TRAE),最常见的是高血压,手脚综合征和贫血. 3/4级TRAE发生在4.8%的患者中.
结论:
- 布罗利祖马布与anlotinib结合,在高级OMM中显示出有希望的疗效和可控的安全性.
- 这种组合疗法需要进一步研究,以确认其对OMM的治疗潜力.
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