工程化Lactobacillus reuteri用于清理反应性氧物种和调节牙周炎治疗中的口腔微生物群
Yuqiang Wang1, Ying Tang1, Qianxiao Huang2
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & Key Laboratory of Oral Biomedicine Ministry of Education & Hubei Key Laboratory of Stomatology & School & Hospital of Stomatology, Wuhan University, Wuhan, China.
International journal of oral science
|February 9, 2026
概括
经过工程改造的 Lactobacillus reuteri 具有 ROS 响应的聚合物,有效地殖民牙周炎部位. 这种益生菌方法减少了氧化应激和致病细菌,抑制了牙周炎的进展.
科学领域:
- 口腔微生物学 口腔微生物学
- 生物材料科学是生物材料的科学.
- 牙周病学 牙周病学
背景情况:
- 牙周炎涉及下牙功能失调和氧化应激.
- 传统的益生菌在氧化性牙周炎环境中面临着殖民挑战.
研究的目的:
- 为牙周炎治疗改造 Lactobacillus reuteri 具有增强的殖民能力.
- 开发一种反应性氧物种 (ROS) 响应的益生菌,以实现向的输送和有效性.
主要方法:
- 通过用酸-多巴胺-氨酸 (PDH) 聚合物 (LR@PDH) 改造的 Lactobacillus reuteri (LR).
- 在实验室中研究了LR@PDH的ROS清除和粘附特性.
- 在牙周炎模型中评估了LR@PDH的治疗效果.
主要成果:
- 在炎症微环境中,PDH聚合物消耗了ROS,并促进了LR粘附.
- 与传统益生菌相比,LR@PDH显著减轻了局部氧化应激.
- 减少了致病性细菌的数量,抑制了牙周炎的进展.
结论:
- 对炎症有反应的粘合剂Lactobacillus reuteri在牙周炎治疗中表现出卓越的疗效.
- 这种工程化益生菌有效地管理氧化应激和下牙功能失调.
- LR@PDH显示出作为牙周炎的安全和生物相容治疗药物的潜力.
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