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Updated: Feb 11, 2026

Investigating Intestinal Barrier Breakdown in Living Organoids
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植物酸 (InsP) 激活HDAC3表观遗传轴,以维持肠道屏障功能

Sujan Chatterjee1, Zachary Sin1, Nguyen Tran1

  • 1Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, NV, USA.

Nature communications
|February 9, 2026
PubMed
概括

伊诺西聚酸多酶 (IPMK) 和植物酸 (InsP6) 激活HDAC3表观遗传轴,这对肠道屏障完整性至关重要. 这一发现为炎症性肠病和漏肠状况提供了潜在的治疗策略.

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