[治疗非肌肉侵入性膀癌]
Mirjam Leeder1,2, Katharina Leucht3,4, Maria Marx3,4
1Klinik und Poliklinik für Urologie, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Am Klinikum 1, 07747, Jena, Deutschland. mirjam.leeder@med.uni-jena.de.
Urologie (Heidelberg, Germany)
|February 9, 2026
概括
高风险的非肌肉侵入性膀癌 (NMIBC) 显示高复发率. 新型疗法,包括用菌卡尔梅特-盖林 (BCG) 的免疫检查点抑制剂,改善了BCG先前未使用的患者的治疗结果,并为BCG耐药病例提供了保持膀的选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 具有显著的复发和进展风险.
- 目前的治疗方法,如通过尿道切除和Bacillus Calmette-Guérin (BCG) 疗法都有局限性,特别是在高风险的NMIBC.
- 对于先进的膀保护治疗策略的需求尚未得到满足.
研究的目的:
- 审查NMIBC目前的治疗环境.
- 评估BCG先前和BCG耐药NMIBC的新型治疗方法.
- 讨论最近在美国批准的静脉内和全身疗法.
主要方法:
- 目前临床指南建议的总结.
- 对结合PD-1/PD-L1抑制剂与BCG用于BCG先前未使用的患者的III期试验的审查.
- 对BCG耐药NMIBC新兴治疗策略的分析.
主要成果:
- 第三期试验显示,BCG加上杜尔瓦卢马布或萨桑利马布在BCG先前未使用的高风险NMIBC中改善了无疾病或无事件生存率.
- 美国批准了几种新的静脉内和全身疗法,用于BCG耐药的NMIBC,支持膀的保存.
- 根性囊切除术仍然是欧洲BCG耐药NMIBC的标准,正在研究创新的治疗方法.
结论:
- NMIBC治疗领域正在迅速发展.
- 组合疗法和新型静脉内疗法在减少复发和进展方面显示出有前途.
- 这些进展旨在扩大BCG的使用范围,并巩固保持膀的治疗模式.
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