在认知炼期间长期COVID中大脑内在连接性受损,由独立组件分析揭示
Leighton Barnden1, James Baraniuk2, Maira Inderyas3
1National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD, Australia. l.barnden@griffith.edu.au.
Scientific reports
|February 9, 2026
概括
长期COVID (LCov) 患者表现出认知功能障碍,脑部成像显示功能连接的改变. 这些变化与疾病持续时间相关,并可能解释长期COVID中观察到的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 认知功能障碍是长期COVID (LCov) 的普遍症状之一.
- 了解LCov相关认知障碍的神经基础至关重要.
研究的目的:
- 描述长期COVID患者大脑中的功能连接性改变.
- 研究这些连接性变化与认知表现之间的关系.
主要方法:
- 在Stroop任务中从19名LCov和16名健康对照 (HC) 参与者获得功能磁共振成像 (fMRI) 数据.
- 利用独立组件分析 (ICA) 来分析群体之间的互联网连接差异,并与疾病持续时间相关.
主要成果:
- 与HC相比,LCov参与者表现出较慢的Stroop反应时间.
- 在Salience,Language,Central Executive,Sensorimotor和Visual网络中观察到网络间连接的显著差异.
- 在LCov中,连接缺陷与更长的疾病持续时间有关,有证据表明特定大脑区域的补偿性增加.
结论:
- 改变大脑功能连接,特别是在支持执行功能和注意力的网络中,有助于长期COVID的认知功能障碍.
- 疾病持续时间会影响这些连接性变化的模式和严重程度.
- 这些发现支持LCov的认知障碍存在,其中可能存在补偿机制.
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