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Updated: Feb 11, 2026

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免疫检查点抑制增加了头癌的抗原特异性T细胞反应

Patrick J Schuler1, Franziska Oliveri2, Lisa Puntigam2

  • 1Department of Otorhinolaryngology, University Hospital Heidelberg, 69120, Heidelberg, Germany. patrick.schuler@med.uni-heidelberg.de.

Scientific reports
|February 9, 2026
PubMed
概括

将抗原特异性疫苗接种与抗PD-1检查点抑制相结合,有望增强头癌的抗瘤免疫反应. 这种方法可以通过增强对瘤的T细胞活性来改善目前的治疗方法.

关键词:
抗LAG-3 (淋巴细胞激活基因3)抗PD-1 (编程死亡-1,aPD-1) 的使用.抗TIM-3 (T细胞免疫球蛋白和含有-3) 的粘真菌域).头癌 (HNC) 是一种头癌.免疫检查站是免疫检查站与黑色素瘤相关的抗原 (MAGE)纽约食道细胞癌1 (NY-ESO-1) 的情况在黑色素瘤中优先表达的抗原 (PRAME)与瘤相关的抗原 (TAA)

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