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在乳腺状甲状腺癌干细胞中JAG1的表达预测预后不佳,并涉及血管新生
Riho Yoshida-Minato1, Tetsuhiro Horie2,3, Mitsuharu Aga1
1Department of Otorhinolaryngology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Discover oncology
|February 9, 2026
概括
甲状腺癌干细胞 (CSCs) 驱动复发. 高干细胞显示了JAG1表达的增加,与预后和血管生成的差异有关,提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 甲状腺癌干细胞 (CSC) 在瘤复发和转移中至关重要.
- 了解CSC的特性和相互作用对于有效治疗至关重要.
研究的目的:
- 为了研究甲状腺CSC类细胞特性,细胞相互作用和预后基因特征.
- 分析单细胞RNA测序 (scRNA-seq) 和临床数据,以获得新的见解.
主要方法:
- 使用Seurat.521,对两个独立的scRNA-seq数据集 (GSE191288,GSE250521) 的分析.
- 通过CytoTRACE识别高干细胞 (类似CSC) 和低干细胞.
- 构建蛋白质-蛋白质相互作用 (PPI) 网络和基因本体学分析.
- 使用CellChat进行细胞细胞相互作用分析和使用TCGA数据进行生存分析.
主要成果:
- 高干细胞在数据集中表现出共同的基因上调,其中枢纽基因与血管生成有关.
- 在JAG1 (高干细胞) 和NOTCH1/4 (内皮细胞) 之间发现了显著的相互作用.
- 甲状腺癌患者的高JAG1表达与高茎度和更差的预后相关.
结论:
- 甲状腺CSC类细胞具有独特的基因表达特征.
- JAG1-NOTCH信号通路相互作用与甲状腺癌进展有关.
- 这项研究为甲状腺CSC及其瘤微环境相互作用提供了新的见解.
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