一个名字有什么意思? 代谢物识别:非向代谢学中的挑战和陷
Georgios Theodoridis1,2, Oliver Fiehn3, Michal Holčapek4
1Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.
Metabolomics : Official journal of the Metabolomic Society
|February 9, 2026
概括
准确的代谢物识别对于非目标代谢学至关重要. 研究中的不良识别标准威胁着科学信誉,需要全社区采取行动进行改进.
科学领域:
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
- 分析化学 分析化学
背景情况:
- 代谢表型化 (metabotyping) 旨在识别用于表征生物状态的代谢物.
- 自信的代谢物识别对于在非目标代谢学中的机理学理解至关重要.
- 当前的代谢物识别标准往往缺乏足够的证据,并且不遵循指南.
研究的目的:
- 用MS-based技术来定义在非目标代谢学中困扰代谢物识别的问题.
- 为了提高人们对错误的代谢物识别的惊人增加的认识.
- 突出不良代谢物识别对代谢学研究可信度的影响.
主要方法:
- 审查当前在代谢物识别方面的挑战.
- 分析基于MS的技术,特别是LC-MS.
- 关于识别错误的示例案例研究的介绍.
主要成果:
- 代谢物识别在代谢学工作流程中仍然是一个有争议和容易出错的步骤.
- 许多出版物对已识别的代谢产物提供了不足的证据.
- 错误的代谢物识别正在增加,并且在同行评审期间经常无法识别.
结论:
- 不良的代谢物识别威胁到非目标代谢学的可信度,并污染了科学文献.
- 研究人员,数据库管理人员和科学出版商需要采取协调行动.
- 解决这个问题对于保持代谢学研究的完整性至关重要.
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