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Updated: Feb 11, 2026

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一种新的方法来生产THC和CBN认证的参考材料
Lucas J de Carvalho1, Silvia Regina Pinheiro Lopes2, Karine Ecard Cesar2
1Organic Analysis Laboratory, National Institute of Metrology, Quality and Technology (Inmetro), Avenida Nossa Senhora das Graças, 50, Duque de Caxias, Rio de Janeiro, Brazil. ljcarvalho@inmetro.gov.br.
Analytical and bioanalytical chemistry
|February 9, 2026
概括
这项研究介绍了一种新方法,用于生产认证参考材料 (CRM),用于像大麻素 (CBN) 和delta-9-tetrahydrocannabinol (Δ9-THC) 这样的大麻素. 开发的方法提高了CBN产量,支持准确的大麻产品分析.
科学领域:
- 分析化学 分析化学
- 计量学 计量学 计量学
- 有机化学 有机化学
背景情况:
- 准确量化大麻素对于大麻产品的法医,监管和质量控制至关重要.
- 一个重大挑战是认证参考材料 (CRM) 的稀缺性,特别是对于像 cannabinol (CBN) 这样的轻微大麻素.
- 现有的方法与CBN的自然丰度低而扎,阻碍了可靠的分析.
研究的目的:
- 开发和表征证书认证参考材料 (CRM) 候选者,用于delta-9-tetrahydrocannabinol (Δ9-THC) 和大麻素 (CBN).
- 为制造这些CRM建立一个综合的分析和准备战略.
- 通过一种高效的转换方法来克服CBN的低自然丰度.
主要方法:
- 使用质子核磁共振 (1H NMR) 用PULCON方法对可追溯质量分数值进行大麻素的量化.
- 在大麻提取物中直接将Δ9-THC转化为CBN的中介氧化转化方法的开发,以丰富CBN.
- 评估CRM可行性通过统一性和运输稳定性研究在计量框架内.
主要成果:
- 成功生产和表征 Δ9-THC 和 CBN CRM 候选物.
- 开发的转换战略导致与直接提取相比,孤立的CBN产量增加了十倍以上.
- 同质性和运输稳定性研究证实了生产大麻素和植物性大麻CRM的可行性.
结论:
- 这项工作为生产大麻素和植物性大麻参考材料提供了一个实用和计量学上健全的框架.
- 已建立的方法支持可靠和可比的大麻素测量,这对于法医和监管应用至关重要.
- 该战略有效地解决了低CBN丰度的挑战,改善了CRM的可用性.
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