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结合微型TESE和三焦型TESE,改善了非阻塞性精子缺血症的精子获取和冷保存结果

Shimi Barda^1,2,3, Noga Fuchs Weizman^4,5,6, Ron Hauser^4,6

¹Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel. shimib@tlvmc.gov.il.

International urology and nephrology

|February 9, 2026

概括

将微剖析丸精子提取 (microTESE) 与三焦点丸精子提取 (TESE) 结合起来,可显著改善非阻塞性亚精性男性的精子提取和冷保存. 这种双重方法最大限度地保护生育能力,并可能减少重复手术.

科学领域:

生殖医学生殖医学
泌尿器科泌尿器科泌尿器科泌尿器科
安德罗学与人类学

背景情况:

非阻塞性精症 (NOA) 对生育能力的保护构成了重大挑战.
传统的丸精子提取 (TESE) 技术可能并不总是产生足够的精子用于冷保存.
优化精子检索率对于最大限度地提高受影响个体的生育潜力至关重要.

研究的目的:

评估在一次会议中将微剖析丸精子提取 (microTESE) 与三焦点丸精子提取 (TESE) 结合的疗效.
为了确定这种综合方法是否能改善NOA男性的精子采集和冷保存结果.
将组合方法的结果与单独执行的每个技术进行比较.

主要方法:

追溯队列研究分析了93名患有NOA的男性,他们接受了连续的微TESE和三焦点TESE.
单独处理和分析每个技术的样本,以便在患者内部进行比较.
测量精子提取率,定量精子产量和冷保存瓶.
组织病理学模式的分类和统计分析 (p < 0.05).

主要成果:

结合方法实现了明显更高的总体精子检索率 (63.4%),相比单独的微TESE (58.1%) 或单独的三焦TESE (54.8%).
在7.5%的病例中,精子仅在微型TESE标本中获取,在3.2%的病例中,在三焦型TESE标本中获取.
与单独使用这两种方法相比,联合方法产生了显著更多的精子单位 (9.9 ± 5.1) 和冷保存瓶 (12.4 ± 2.4).
对成功检索的组织病理学分析显示出混合缩模式,支持组合向和系统采样的理由.

结论:

结合微型TESE和三焦型TESE的双技术方法显著提高了非阻塞性精症的精子检索和冷保存结果.
这一策略通过增加精子产量和冷样本来最大限度地提高生育能力的保护潜力.
结合方法可以减少在NOA的男性中重复丸精子提取程序的必要性.

关键词:

辅助生殖技术是一种辅助生殖技术.亚精子缺血症 (Azoospermia) 是一种结冷保存是一种冷保存.男人不孕不育的情况精子采集精子采集

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