数字双胞胎大脑揭示了 tinnitus 中异常大脑动态的特定状态刺激目标
Jiaqi Zhang1,2,3, Shuting Han4, Yongcong Shen5
1Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
BMC medicine
|February 10, 2026
概括
数字双胞胎大脑模型通过识别不同的大脑状态来预测耳中的重复性横磁刺激 (rTMS) 效应. 这种方法可以实现个性化的非侵入性脑刺激,以改善声治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 计算精神病学是一种计算精神病学.
背景情况:
- 耳影响全球10-15%的成年人,有效治疗方法有限.
- 重复性横磁性刺激 (rTMS) 是有前途的,但由于个体间的变化,需要精确的目标选择.
- 在耳中确定rTMS的因果目标对于治疗疗效至关重要.
研究的目的:
- 通过使用数字双胞胎大脑 (DTB) 识别与缓解耳相关的功能异常有因果关系的大脑区域.
- 探索声进展中的异常大脑状态的演变.
- 验证DTB衍生因果反应图对rTMS结果的预测能力.
主要方法:
- 使用89名参与者的多式神经成像数据开发了一种特定于耳的DTB.
- 通过超过164万个虚拟rTMS模拟生成因果反应地图.
- 整合全脑基因表达数据和使用独立的rTMS数据集验证的预测.
主要成果:
- 在耳中确定了两个连续的异常大脑状态,与体运动和默认模式网络相关.
- 来自DTB的地图显示,不同的区域 (感官的parieto-occipital,认知的dorsolateral前额皮层) 对于调节这些状态至关重要.
- 与耳风险基因表达相关的因果反应图和准确预测的rTMS效应 (感官:r>0.85;认知:r>0.78).
结论:
- 耳中的大脑功能变化随着疾病的进展而演变.
- DTB可以预测rTMS对不同耳相关的大脑状态的影响.
- 这种DTB方法支持更精确,更有针对性的非侵入性脑刺激来治疗耳.
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