区分等级和头部和部状细胞癌的综合阳性得分相关性
Lifei Feng1, Gaofei Yin1, Wen Gao1
1Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
World journal of surgical oncology
|February 10, 2026
概括
对于PD-L1表达的综合阳性得分 (CPS) 在头癌子部位上有显著差异. CPS与下喉和喉癌的瘤分化有关,影响免疫疗法反应预测.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 头部和部癌 (HNCs) 是常见的恶性瘤,预后不佳,主要是状细胞癌 (SCC).
- 综合阳性得分 (CPS) 评估PD-L1表达,并预测固体瘤的免疫治疗反应.
- 在不同HNC子站点中CPS的分布和临床相关性尚不清楚.
研究的目的:
- 调查PD-L1表达的模式,通过CPS量化,在各种头部和部SCC子站点.
- 探索CPS和临床病理特征之间的相关性,包括瘤分化.
- 在免疫治疗的背景下,评估CPS和患者生存结果之间的关联.
主要方法:
- 在2022年1月至2024年11月期间接受治疗的591名HNC患者的回顾性分析.
- 使用PD-L1 IHC 22C3 pharmDx试验评估PD-L1表达,并进行CPS计算.
- 统计分析包括比较测试,相关性分析和生存分析 (OS,PFS).
主要成果:
- 与口腔癌相比,CPS在下癌中明显较低 (P < 0.05).
- 在下喉癌和喉癌中,CPS与瘤分化有负相关性 (分别P=0.018和P=0.054).
- 在整体免疫疗法亚组中,基于CPS值 (≥20对<20) 的OS或PFS没有显著差异,但在CPS<20的下癌中,生存率较差的趋势.
结论:
- 在HNC子站点的免疫微环境中存在显著的异质性.
- CPS和瘤分化之间的关系是特定于特定地点的.
- 作为一种免疫疗法生物标志物,CPS需要考虑到瘤的解剖起源进行解释.
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