一个多功能工程平台,用于制造假体静脉,使用电
Dario Arcuti1, Salma Mansi1, Dominic Biebl1
1TUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.
这项研究引入了为假体静脉 (PVV) 制造的新型制造平台,可以防止血栓形成和叶片变厚. 创新的设计确保了卓越的水力动力性能,并支持内皮质化,克服了静脉替换的先前局限性.
科学领域:
- 生物材料工程 生物材料工程
- 血管外科 血管外科
- 再生医学是一种再生医学.
背景情况:
- 慢性静脉功能不充分影响数百万由于膜无能.
- 现有的假体静脉 (PVV) 由于血栓形成和因细胞过度生长而导致的叶片变厚而失败.
- 需要一种新的方法来创建功能和持久的光伏电池.
研究的目的:
- 开发一种超越先前设计局限性的皮PVV制造平台.
- 创建防止血栓形成和叶片加厚的PVV.
- 为了证明平台在各种心血管应用中的多功能性.
主要方法:
- 开发了一个制造平台,将支架支架嵌入电纤维中,以创建传单.
- 使用热塑性聚氨 (TPU) 和弹性类似重组聚合物 (ELRs) 等材料的双电.
- 制造双形PVV和经过试验的三形儿科心脏门在体外和根据ISO 8540标准.
主要成果:
- 电矩阵将叶片从细胞中分离出来,并从血液中分离出来,防止过度增生.
- ELR/TPU构造显示了最小的血小板粘附,没有血液溶解,并在体外支持内皮质化.
- 功能评估证实了出色的水力动力性能;儿童心脏门符合ISO 8540标准.
结论:
- 这种新型电平台可以制造具有改善血红相容性和血动力学功能的PVV.
- 该平台为静脉置换和其他心血管设备应用提供了多功能解决方案.
- 这项技术有望解决治疗慢性静脉不全和儿科心脏病的未满足需求.
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