光调节镜头 球形等效和正的结果来自FDA批准后的研究
Jack T Holladay1, Matt Haller2
1Dr. Holladay is a consultant to RxSight, Aliso Viejo, California, USA and Clinical Professor, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
Journal of cataract and refractive surgery
|February 10, 2026
概括
与传统的托里克眼内透镜 (IOL) 相比,Light Adjustable Lens (LAL) 显示出在减少残留白症和改善球形等效方面具有优异的结果. 这导致更好的未经纠正的距离视觉敏度和患者满意度.
科学领域:
- 眼科医生 眼科 眼科
- 生物医学工程 生物医学工程
- 临床研究 临床研究
背景情况:
- 内眼镜 (IOL) 广泛用于在白内障手术期间纠正.
- 由于手术前测量不准确性和手术变异性,使用胸部内膜眼镜实现最佳的折射结果可能具有挑战性.
- 光调节镜头 (LAL) 提供了一种独特的方法,具有术后调整能力.
研究的目的:
- 为了比较折射结果,特别是残留白和球形等效 (SEQ),在光调节镜头 (LAL) 和两个当代的托里克IOL之间.
- 评估LAL在治疗先前存在的角膜纹症方面的有效性.
- 评估LAL的调整能力对未经纠正的远视敏度 (UDVA) 的影响.
主要方法:
- 一个随机的前病例系列,涉及332名先前患有角膜纹症的成年人,他们接受了LAL.
- 与两个对照数据集进行比较:使用AcrySof IQ IOL (SN6AT) 的111只眼睛和使用enVista IOL (MX60ET) 的101只眼睛.
- 从美国各地的手术场所收集的数据.
主要成果:
- 与SN6AT (0.36 D) 和MX60ET (0.38 D) 相比,LAL小组的残留白症的平均绝对误差 (MAE) 较低 (0.26 D).
- 较高的百分比的LAL眼睛实现了残留白 ≤0.50 白 D (92.5%) 与SN6AT (76.6%) 和MX60ET (76.2%) 相比.
- 在93.1%的LAL病例中,达到了≤0.50 D的SEQ,超过了SN6AT (83.8%) 和MX60ET (87.1%). 在LAL (-0.02) 与SN6AT (0.08) 和MX60ET (0.10) 之间,UDVA也更优越.
结论:
- 拉尔手术后的调整能力显著减少了残留的纹,并改善了球形等效.
- 这些折射能力的改善转化为增强未经纠正的远距离视觉敏度.
- 该LAL系统提供了一个有前途的替代方案,用于阿斯蒂格玛症的管理,可能导致更大的患者满意度.
相关概念视频
FDA Approved Drugs: Changes to Approved Drugs
273
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
273
Spherical Coordinates
16.2K
Spherical coordinate systems are preferred over Cartesian, polar, or cylindrical coordinates for systems with spherical symmetry. For example, to describe the surface of a sphere, Cartesian coordinates require all three coordinates. On the other hand, the spherical coordinate system requires only one parameter: the sphere's radius. As a result, the complicated mathematical calculations become simple. Spherical coordinates are used in science and engineering applications like electric and...
16.2K
The Anchoring-and-Adjustment Heuristic
7.8K
In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
7.8K
Pharmaceutical Equivalents
208
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
208
Equivalent Capacitance
2.2K
Multiple capacitors can be connected in a circuit in series or parallel configuration. When the capacitor combination is connected to a battery, the potential drop across each capacitor and the magnitude of charge stored in the individual capacitor depends on the type of the connection. The capacitor combination is replaced by a single equivalent capacitor that stores the same amount of charge as the combination for a given potential difference.
The following strategies are adopted to calculate...
The following strategies are adopted to calculate...
2.2K
Distance Corrections
299
To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
299


