生物仿真尿道芯片平台用于模拟纤维化:在BAM功能化的微环境中进行3D打印和近场电
Jiafu Liu1,2, Wenzhuo Fang1, Kai Wang3
1Department of Urology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Advanced materials (Deerfield Beach, Fla.)
|February 10, 2026
概括
研究人员开发了一种新的尿道上芯片模型来研究尿道收缩纤维化. 这种仿生平台准确地复制了尿道组织的复杂性,为药物查和了解疾病机制提供了一个新的工具.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 尿道狭窄,标志着尿道周纤维化,显著损害尿功能和生活质量.
- 尿道狭窄的频繁复发凸显了研究和药物开发中需要先进的体外模型的需要.
研究的目的:
- 开发一个仿生尿道上芯片平台,复制本地尿道微环境.
- 为研究尿道纤维化机制和查抗纤维菌疗法建立一个生理学上相关的模型.
主要方法:
- 微流体,3D打印和近场电的整合,以创建一个多层微流体设备.
- 使用了聚二甲基 (PDMS) 微通道和一个用膀非细胞基质 (BAM) - 凝生物墨水功能化的聚烯 (PCL) 膜.
- 在动态 perfusion 下使用双层微室共同培养纤维细胞和尿细胞以模拟生理条件.
主要成果:
- 该平台成功模仿了尿道纤维化,包括纤维细胞激活和上皮损伤,经过转化生长因子β1 (TGF-β1) 的刺激.
- 在模型中,拉帕米辛治疗在减轻纤维化反应方面表现出有效性,验证了其用于药理学测试的使用.
- 开发的系统在模拟尿道纤维化方面表现出强度,可重复性和成本效益.
结论:
- 芯片上的尿道平台为研究尿道狭窄和纤维化提供了一个复杂而可靠的模型.
- 这种创新的器官芯片系统具有很大的潜力,可以促进泌尿病学领域的翻译研究和个性化医学.
- 该模型是评估抗纤维菌治疗药物的疗效和加速药物发现的宝贵工具.
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