空气污染和多发性硬化症的风险和进展:系统性审查和元分析
Ahmad A Toubasi1, Thuraya N Al-Sayegh2
1Department of Neurology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.
Annals of clinical and translational neurology
|February 10, 2026
概括
暴露于空气污染,特别是细颗粒物 (PM2.5) 和一氧化碳 (CO),与增加多发性硬化症 (MS) 风险有关. 短期暴露于PM2.5,PM10,二氧化 (NO2) 和臭氧 (O3) 等污染物与MS严重程度相关.
科学领域:
- 环境健康 环境健康
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 空气污染是各种神经疾病的已知危险因素.
- 之前关于空气污染和多发性硬化症 (MS) 的研究已经产生了相互矛盾的结果,通常是由于样本大小小小.
研究的目的:
- 调查暴露于特定空气污染物和多发性硬化症 (MS) 的风险和严重程度之间的关联.
- 综合观察性研究的证据,以全面了解空气污染对MS的影响.
主要方法:
- 在PubMed,Embase,Scopus和Cochrane CENTRAL进行了系统的文献搜索,截至2025年9月9日.
- 包括的观察性研究评估了PM2.5,PM10,NO2,CO,SO2,O3暴露与MS风险或严重程度之间的关联.
- 使用固定或随机效应模型将危险比率 (HRs) 和95%置信区间 (CI) 进行了聚合.
主要成果:
- 长期暴露于PM2.5,PM10和CO与患MS的风险增加有关.
- 短期暴露于PM2.5,PM10,NO2和O3与MS复发的增加有关.
- 暴露于PM2.5和PM10与增强对比度的病变 (CEL) 相关,而PM10与残疾进展有关.
结论:
- 长期暴露于空气污染物增加了多发性硬化症 (MS) 的风险.
- 短期暴露于空气污染物与更严重的MS疾病严重程度有关,包括复发和残疾进展.
- 降低空气污染水平可能是保护多发性硬化症患者大脑健康的关键公共卫生策略.
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