低温的败血症患者的温度轨迹:当冰开始融化时-一项回顾性队列研究
Chang Xu1, Keying Ding2, Xiaoyang Zhou1
1Department of Intensive Care Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Science progress
|February 10, 2026
概括
鉴定低温的败血症患者的明显温度模式至关重要. 发现了三个温度轨迹,与增加或减少死亡率相关的特定模式,有助于早期识别"感冒败血症".
科学领域:
- 关键护理医学 关键护理医学
- 败血症病理生理学病理生理学
- 热调节在疾病中的作用
背景情况:
- 败血症是一种复杂的疾病,患者的结果各不相同.
- 败血症的低温通常与预后较差有关.
- 亚表型化败血症可能会改善临床管理策略.
研究的目的:
- 在呈低温症的败血症患者中识别不同的温度轨迹亚现型.
- 调查这些温度轨迹与临床结果 (包括死亡率) 之间的关联.
- 探索温度模式的潜力,以早期识别严重败血症病例.
主要方法:
- 使用MIMIC-IV数据库进行的回顾性观察研究.
- 基于组的轨迹建模来分类48小时的温度模式.
- 考克斯的比例危险模型和双重可靠的估计来分析死亡率关联.
主要成果:
- 在1816名患有低温的败血症患者中,确定了三个不同的温度轨迹类.
- 1类与2类 (HR 1.90) 相比,与7天死亡率显著增加有关.
- 与第二类相比,第三类显示出28天死亡率下降的趋势 (HR 0.81).
结论:
- 在低温败血症患者中存在不同的温度轨迹,与不同的临床结果相关.
- 这些发现凸显了败血症呈现和进展的异质性.
- 了解这些温度模式可能有助于更早地识别患有严重"感冒败血症"的患者.
相关概念视频
Phase Transitions: Melting and Freezing
15.3K
Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
15.3K
Orthogonal Trajectories
71
Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
71
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility
51.7K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
51.7K
Effects of Temperature on Free Energy
28.4K
The spontaneity of a process depends upon the temperature of the system. Phase transitions, for example, will proceed spontaneously in one direction or the other depending upon the temperature of the substance in question. Likewise, some chemical reactions can also exhibit temperature-dependent spontaneities. To illustrate this concept, the equation relating free energy change to the enthalpy and entropy changes for the process is considered:
28.4K
Bioavailability Study Design: Healthy Subjects Versus Patients
162
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
162
Body Temperature
4.9K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
4.9K


