精液冷保存在丸癌:在花切除术之前还是之后?
Alessandra Buonacquisto1,2, Carlotta Pozza3, Gaia Cicolani1
1Laboratory of Seminology "Loredana Gandini" Sperm Bank, Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
Andrology
|February 10, 2026
概括
对于丸癌患者来说,化术后的冷保存能产生具有更好的DNA完整性的精子,尽管数量较低. 对于个性化的生育保护策略来说,详细的雄性病学评估至关重要.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 安德罗学与人类学
背景情况:
- 保护生育能力是丸癌症患者的一个关键问题.
- 关于精子冷保存相对于兰花切除术的最佳时间是有争议的.
研究的目的:
- 为了确定精液冷保存的最佳时间.
- 确定辅助生殖技术 (ART) 的最佳样本质量.
- 为了评估精液参数,荷尔蒙特征,超声波和精子DNA碎片化 (SDF) 在除术前后.
主要方法:
- 综合的精液分析.
- 激素分析 (FSH,LH,丸激素).
- 丸超声波和精子DNA碎片化 (SDF) 的评估.
主要成果:
- 带切除术后的样本显示精子数量和运动率下降,但显著减少了SDF.
- 术前FSH升高和BMI升高与术后精子数量较低有关.
- 反侧丸体积影响了SDF的改善;异质性与益处较小有关.
结论:
- 对于个性化的生育保护,详细的雄性病学评估 (精液分析,激素,超声波) 是至关重要的.
- 尽管传统参数较差,但 post-orchidectomy精子在ART中提供了优越的DNA完整性.
- 这表明手术后的样本可能更适合用于生育治疗.
相关概念视频
Sperm Structure and Semen Composition
11.5K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
11.5K
Cancer
54.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
What is Cancer?
14.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K
Cancer Prevention
8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.2K
Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Cancer Vaccines
1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K


