用于药物输送的静脉内植入物:临床疗效,安全性和翻译视角
Carolina Nunes da Silva1, Thomas Toshio Inoue1, Marina França Dias2
1Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Expert opinion on drug delivery
|February 10, 2026
概括
持续释放的静脉内药物递送系统 (DDS) 通过允许长时间的药物递送,可以改善慢性视网膜疾病的治疗. 需要进一步的创新来优化安全性,疗效和可制造性,以获得更好的患者结果.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性视网膜疾病会导致不可逆转的视力丧失,需要频繁的视内注射.
- 目前的治疗方法,如抗VEGF药物和皮质类固醇,具有局限性,包括高治疗负担和累积风险.
- 持续释放的静脉内药物输送系统 (DDS) 旨在通过延长治疗活性和改善患者坚持治疗来克服这些局限性.
研究的目的:
- 审查内DDSs的演变和临床潜力.
- 讨论聚合物设计,水凝,现场成型系统和3D打印的DDS方面的进展.
- 检查内DDS的临床转化障碍.
主要方法:
- 在PubMed,Scopus,Web of Science,ClinicalTrials.gov和监管存储库中进行全面的文献搜索.
- 审查到2025年12月发布的数据.
- 对非生物降解和生物降解的静脉内DDS的分析.
主要成果:
- 静脉内DDS正在推进长期局部药物释放的眼部药物治疗.
- 目前正在开发各种DDS技术,包括植入物和现场成形系统.
- 关键的配方,临床前和监管挑战影响临床翻译.
结论:
- 静脉内DDS准备重新定义视网膜药物治疗.
- 在生物材料,聚合物设计和灭菌方面进一步创新至关重要.
- 整合精准医学和先进的生物材料将导致优化,最少的侵入性视网膜疗法.
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