在患有中风后认知障碍的患者中升高miR-502-3p的预后值
Yi Lin1, Liang Xu2, Yuhao Zhang3
1Department of Nursing, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, China.
Brain and behavior
|February 10, 2026
概括
血清上升的miR-502-3p是中风后认知障碍 (PSCI) 的有希望的生物标志物. 这一发现与高血压一起,确定了中风后发展PSCI的关键风险因素.
科学领域:
- 生物标志物 生物标志物
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 脑卒中后认知障碍 (PSCI) 是中风后的常见并发症.
- 微RNA-502-3p (miR-502-3p) 在血管和神经退行性疾病中起作用,但其在PSCI中的功能尚不清楚.
研究的目的:
- 在PSCI患者中研究miR-502-3p的差异表达.
- 评估miR-502-3p表达水平对PSCI的预测值.
主要方法:
- 量化PCR (qPCR) 用于测量112名PSCI患者和161名对照者的血清miR-502-3p水平.
- 接收器操作特征 (ROC) 曲线分析评估了PSCI的miR-502-3p的预测准确性.
- 皮尔森相关性和多变量逻辑回归确定了相关性和风险因素.
主要成果:
- 在PSCI组中,血清miR-502-3p水平明显高于PSCI组.
- ROC曲线分析显示面积为0.850,灵敏度为76.79%,特异性为77.64%.
- 升高的miR-502-3p水平与NIHSS和mRS得分正相关,与MoCA得分负相关. 高血压也被确定为一个独立的危险因素.
结论:
- 显著升高的血清miR-502-3p作为PSCI发作的潜在生物标志物.
- 升高的miR-502-3p和高血压都是发展PSCI的独立危险因素.
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