韩国肺外结核病的耐药性,2010-2019:与肺结核病的比较
Saerom Kim1,2, Doosoo Jeon3,4, Taehoon Lee5
1Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Journal of Korean medical science
|February 10, 2026
概括
外肺结核 (EPTB) 正在增加,与肺结核 (PTB) 相比,药物耐药率较低. 持续监测EPTB中药物耐药性趋势对于有效的患者管理至关重要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在肺外结核 (EPTB) 患者中研究药物耐药性模式.
- 将EPTB耐药性与肺结核病例进行比较.
- 分析了韩国十年来抗药性趋势.
研究的目的:
- 确定EPTB患者的耐药性状况和趋势.
- 为了比较EPTB和PTB之间的耐药性概况.
- 为管理EPTB的战略提供信息.
主要方法:
- 对表型药物敏感性测试 (DST) 结果的回顾性分析.
- 包括来自韩国七家医院 (2010-2019) 的培养确认结核病 (TB) 病例.
- 对EPTB和PTB患者组的比较 (共10557人).
主要成果:
- 在所有结核病例中,EPTB比例增加.
- 斑膜,淋巴结和骨/关节是常见的EPTB地点.
- 与PTB相比,新的EPTB患者对异化 (8.5%) 和利芬素 (2.4%) 的抵抗率较低.
- 在这两组中,多抗药/瑞芬素耐药结核病 (MDR/RR-TB) 的发生均有下降.
结论:
- 提供韩国EPTB耐药性关键数据.
- 强调需要在EPTB中持续监测耐药性.
- 强调更新药物敏感性测试数据库,以改善EPTB管理.
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