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Updated: Feb 11, 2026

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Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages
Published on: May 24, 2019
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纳米粒子封装在apoptotic体中,通过乳酸介导的巨细胞两极分化调节炎症
Hai-Cun Zhou1, Jian-Ping Long1, Tao Yang1
1Gansu Maternal and Child Health Care Hospital, Lanzhou, PR China.
Annals of medicine
|February 10, 2026
概括
这项研究开发了封装乳酸的新型纳米颗粒来治疗炎症. 这些纳米粒子有效降低了炎症,并促进了巨细胞两极分化,没有有毒的副作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 免疫学 免疫学 免疫学
背景情况:
- 炎症与众多疾病有关,构成了全球健康的重大挑战.
- 乳酸及其信号通路显示出通过巨细胞极化抑制炎症的潜力,没有毒性副作用.
研究的目的:
- 为了创建一个药物输送系统,以有针对性的乳酸释放.
- 开发一种安全有效的抗炎纳米疗法.
主要方法:
- 巨细胞衍生的亡体 (ABs) 用于创建AB封装的纳米粒子 (ABNs).
- 乳酸释放,安全性和ABN的抗炎作用在体外和体内都得到了评估.
- 分析了巨细胞的表型分布和关键的炎症标志物.
主要成果:
- 激活的巨细胞选择性地吸收了ABN,减少了炎症标志物和活性氧物种.
- ABNs缓解了结肠和肝炎,降低了血清TNF-α和IL-1β,并抑制了TLR4/NF-κB信号传递.
- ABNs促进了M1到M2的巨细胞分化,没有观察到细胞毒性.
结论:
- 通过乳酸释放,ABN有效调节巨细胞表型,在小鼠模型中减轻炎症和损伤.
- 开发的纳米系统显示了作为一种乳酸输送平台的承诺,用于减少炎症.
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