准脊椎阻塞与胸腔外周阻塞在减少慢性胸切除术后疼痛方面的临床和成本效益: TOPIC2 RCT摘要
Ben Shelley1,2, Lee Middleton3, Andreas Goebel4,5
1Anaesthesia, Perioperative Medicine and Critical Care Research Group, University of Glasgow, Glasgow, UK.
Health technology assessment (Winchester, England)
|February 10, 2026
概括
副脊椎阻塞和胸腔外周阻塞在预防六个月的慢性胸切除术后疼痛方面表现出类似的有效性. 这两种技术都是NHS环境中胸部手术疼痛管理的可行选择.
科学领域:
- 胸部外科手术 胸部外科手术
- 疼痛管理 疼痛管理
- 麻醉学 麻醉学
背景情况:
- 慢性胸切除术后疼痛影响超过三分之一的患者,持续数月或数年.
- 有效的术后疼痛管理对于减轻慢性疼痛的风险至关重要.
研究的目的:
- 为了比较准脊椎阻塞与胸腔外周阻塞的临床和成本效益.
- 测试副脊椎阻塞是否可以降低慢性胸切除术后疼痛的发生率.
主要方法:
- 一个多中心,随机对照试验与综合健康经济评估.
- 经过胸切除术的成年患者被随机分配到接受准脊椎阻塞或胸部外周阻塞.
主要成果:
- 在6个月后,慢性疼痛的发生率为22%的副脊椎阻塞和16%的胸部外周阻塞 (p=0.12).
- 第1天的急性疼痛在准脊椎阻塞下更高,但并发症是可比的.
- 胸腔外围注射阻塞显示了改善质量调整寿命和降低成本的趋势,但差异在统计学上并不显著.
结论:
- 副脊椎阻塞和胸部外周阻塞在临床和成本效益方面是相当的,用于预防6个月后的慢性胸切除术后疼痛.
- 这两种技术都可能继续在NHS胸部环境中使用,以临床医生和患者的偏好为指导.
关键词:
慢性疼痛是一种慢性疼痛.脑神经阻塞 脑神经阻塞区域麻醉剂 区域麻醉剂胸部麻醉剂 胸部麻醉剂 胸部麻醉剂胸腔外皮阻塞 胸腔外皮阻塞 胸腔外皮阻塞胸部手术 胸部手术胸腔切除术 (THORACOTOMY) 是一个切除术.更多相关视频
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