相关实验视频
Updated: Feb 11, 2026

10:29
Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
2.4K
在住院接受化学抗原受体T细胞治疗的患者中,细胞巨乳病毒感染和临床结果
Muhammad Atif Khan1, Muhammad Shafiq1, Mehran Ali Khan2
1Internal Medicine, University of Kansas Medical Center, Kansas City, USA.
Cureus
|February 10, 2026
概括
在接受仿真抗原受体T (CAR-T) 细胞治疗的患者中,细胞巨乳病毒 (CMV) 感染与更高的死亡率和更长的住院时间有关. 早期的CMV检测和管理对于改善CAR-T接受者的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 化学抗原受体T (CAR-T) 细胞疗法为治疗血液恶性瘤提供了一种革命性的方法.
- 卡尔-T疗法与显著的毒性有关,包括诸如细胞巨型病毒 (CMV) 这样的机会性感染.
- 关于CMV在CAR-T接受者的临床影响的数据有限.
研究的目的:
- 评估在接受CAR-T细胞治疗的患者中与细胞巨乳病毒 (CMV) 感染相关的临床结果.
- 评估CMV感染对死亡率,住院时间和患者群体中特定并发症的影响.
主要方法:
- 使用2021年医疗保健成本和利用项目-国家再接收数据库 (HCUP-NRD) 的回顾性队列研究.
- 包括因多发性骨髓瘤,非霍奇金淋巴瘤或急性白血病而接受CAR-T治疗的住院成年患者.
- 使用倾向性得分匹配和加权分析来比较CMV阳性和CMV阴性组之间的结果.
主要成果:
- 在2.2%的CAR-T住院病例中发现了CMV感染.
- 在匹配的队列中,CMV感染与显著更长的逗留时间 (41.5 vs. 15.9天) 和脑病变风险增加有关 (RR 13.21).
- 在CMV阳性患者中,三个月死亡率显著高 (15.8%与2.5%相比).
结论:
- 在CAR-T接受者中,CMV感染与增加住院死亡率和延长住院时间有关.
- 在CMV感染的CAR-T患者中观察到脑病变的风险较高.
- 对于这种高风险人群来说,对CMV进行警监测和早期管理至关重要.
更多相关视频
相关概念视频
Hospitals-II
1.2K
Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
Nurses that work in...
1.2K
Diversity of Antigen Receptors
1.7K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.7K
Hospitals-I
1.7K
Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.7K
Endocarditis II: Clinical Features of Infective Endocarditis
552
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
552
Antigen Presenting Cells
3.4K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.4K
Outcomes of Glycolysis
107.6K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.6K

![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)