生物医学应用中的活体水凝:最近的进展和未来的前景
Chenyu Shen1, Ying Wang1, Xinzhou Xiao2
1Basic Medical Research Center, Medical School, Nantong University, Nantong 226001, Jiangsu Province, China. chengang6626@ntu.edu.cn.
Journal of materials chemistry. B
|February 10, 2026
概括
水凝模仿生物医学用途的本地组织. 本综述涵盖了它们的特性,先进的体内应用,如组织修复和药物输送,以及临床翻译的未来挑战.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 医疗设备工程 医疗设备工程
背景情况:
- 水凝是富含水的聚合物网络,模仿本地组织特性.
- 在体内应用对于诊断,治疗和组织再生至关重要.
- 快速的进步需要更新水凝技术的概况.
研究的目的:
- 为生物医学应用提供当前水凝技术的全面审查.
- 将进展置于背景中,并指导该领域的未来研究.
- 分析材料特性和性能要求,用于特定的in vivo用例.
主要方法:
- 对水凝选择和特性 (机械,生物相容性,响应性) 的最新进展的审查.
- 检查各种体内应用,包括3D生物打印,可植入电子,粘合剂,伤口愈合和药物输送等.
- 对临床翻译的挑战和前景的分析.
主要成果:
- 探索用于组织重建的3D生物打印水凝.
- 讨论基于水凝的可植入电子设备,用于传感和刺激.
- 强调用于药物输送,伤口愈合和再生疗法 (软骨,神经) 的水凝系统.
结论:
- 水凝对各种in vivo生物医学应用具有显著的前景.
- 关键的挑战包括免疫兼容性,机械稳定性和长期功能.
- 需要策略来加快临床翻译和增强功能多功能性.
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