短时间内皮层抑制与人类大脑中高频皮层-皮层功能连接有关
Silvio Bagetta1, Federico Carparelli1, Valerio Ferrari1
1Department of Systems Medicine, Tor Vergata University, Via Montpellier 1, Rome 00133, Italy.
Cerebral cortex (New York, N.Y. : 1991)
|February 10, 2026
概括
通过配对脉冲横磁刺激 (pp-TMS) 测量的短间隔皮层内抑制 (SICI) 与大脑网络连接有关. 在β和gamma频段中功能连接的强度与健康成年人皮质抑制的减少相关.
科学领域:
- 神经科学是一个神经科学.
- 神经生理学 神经生理学
- 脑部成像 脑部成像
背景情况:
- 短间隔皮质内抑制 (SICI) 是GABA-A介导皮质抑制的标志物.
- 之前的研究已经局部描述了SICI,但其与大规模大脑网络动态的联系尚不清楚.
研究的目的:
- 研究SICI中个体间变异性与静止状态功能连接 (FC) 之间的关系.
- 探索GABA-A介导的抑制如何影响皮质网络组织.
主要方法:
- 在18名健康志愿者中使用高密度脑电图 (HD-EEG) 和配对脉冲横磁刺激 (pp-TMS).
- 静止状态的FC在源空间中使用跨频段的加权相位滞后指数计算.
- 基于网络的统计数据被用来将SICI与有条件的运动唤起潜能 (MEP) 联系起来.
主要成果:
- 在β和高马波段中更强的FC与减少SICI (在2毫秒的刺激间隔中更大的有条件MEP) 相关.
- 这些特定频率的网络涉及传感器,前额,角-角和角-角区域.
结论:
- 这项研究提供了第一个电生理学证据,将局部皮质抑制与大规模,频率特定的大脑网络联系起来.
- 这些发现促进了对GABA-A抑制在塑造大脑网络组织中的作用的理解,并表明了研究神经系统疾病的潜在应用.
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