吸烟行为与前列腺癌的免疫格局变化有关:对患者结果的影响
Amod Sharma1,2, Sarabjeet Kour Sudan1,2, Mohammad Aslam Khan3
1Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
The Prostate
|February 10, 2026
概括
积极吸烟促进前列腺癌 (PCa) 中的免疫抑制性瘤微环境 (TME),增加调节性T细胞和瘤相关的巨细胞. 戒烟可以逆转这些免疫变化,改善PCa患者的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 吸烟是前列腺癌 (PCa) 诊断,复发和死亡率的已知危险因素.
- 吸烟对PCa中瘤微环境 (TME) 免疫格局的影响尚不清楚.
- 这项研究探讨了吸烟如何改变PCa免疫特征及其与患者存活时间的相关性.
研究的目的:
- 研究吸烟对PCa TME内的免疫细胞组成的影响.
- 在PCa中识别与吸烟相关的特定免疫路径和基因表达变化.
- 确定吸烟引起的免疫变化与PCa患者存活率之间的关联.
主要方法:
- 吸烟者和非吸烟者的瘤组织中免疫细胞的多重基因表达分析,使用nanoString nCounter® PanCancer免疫分析面板.
- 使用Enrichr进行生物信息分析,以确定差异激活的途径.
- 对公共数据库的调查,以将基因表达和免疫细胞丰度与患者生存数据相关联.
主要成果:
- 与非吸烟者相比,目前吸烟者显示瘤相关巨细胞 (TAMs) 和调节性T细胞 (Tregs) 的透率显著更高.
- 观察到TAMs和Tregs之间存在强烈的正相关性,特别是在目前的吸烟者中.
- 在吸烟者中发现了免疫抑制途径的上调 (例如PD-L1表达) 和抗原呈现途径的下调.
- 关键的上调基因 (MAGEA3,POU2AF1,SEMG1) 与免疫抑制和较差的生存率相关.
- 高TAM和Treg透显著与降低整体存活率相关.
结论:
- 积极吸烟会诱导前列腺癌中的免疫抑制性TME,可能促进瘤的生长和进展.
- 这些吸烟引起的免疫变化与较差的患者生存结果有关.
- 戒烟可能提供一种策略来逆转这些免疫抑制作用并改善PCa疾病的结果.
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