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单原子纳米酶:用于中枢神经系统疾病研究的新平台

Yue Yang¹, Ya-Qi Zhu¹, Su-Yun Zhang¹

¹School of Pharmacy, Nantong University, Nantong, 226001, P. R. China. Zhangxiaoling@ntu.edu.cn.

Chemical communications (Cambridge, England)

|February 10, 2026

概括

单原子纳米酶 (SAzymes) 通过克服血脑屏障,为中枢神经系统 (CNS) 疾病提供了先进的治疗潜力. 本综述探讨了SAzyme在神经保护中的应用,并提出了治疗脑损伤和神经退行性疾病的新策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
神经科学是一个神经科学.

背景情况:

中枢神经系统 (CNS) 易受炎症损伤的影响,由于血脑屏障 (BBB) 的存在,药物透率有限.
新的治疗策略对于治疗中枢神经系统损伤和神经退行等疾病至关重要.

研究的目的:

系统地审查单原子纳米酶 (SAzymes) 作为中枢神经系统疾病的有前途的治疗平台.
讨论SAzymes在治疗脑损伤,中风和神经退行性疾病中的作用和潜力.

主要方法:

关于单原子纳米酶 (SAzymes) 的综合文献综述,包括碳材料,MOF,金属氧化物和金属硫化物.
分析SAzyme的特性,如抗炎和抗菌作用.
探索SAzyme在神经保护,生物监测和疾病治疗中的应用.

主要成果:

与传统纳米酶相比,SA酶具有独特的优势,包括增强的催化活性和可调节性质.
各种SA酶在治疗脑损伤,中风和神经退行性疾病方面表现出显著的潜力.
在生物监测和神经保护方面,SA酶显得有前途.

结论:

SA酶代表了中枢神经系统疾病的新和有效的治疗策略,克服了BBB的局限性.
对SAzymes的进一步研究可能会导致神经系统疾病的先进治疗方法.
确定了SAzymes在中枢神经系统治疗中的关键挑战和未来研究方向.

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