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Updated: Feb 11, 2026

Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes
10:14

Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes

Published on: October 25, 2014

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染色体重塑器BAF保持HBVccDNA转录能力,并代表一个治疗点

Dan Huang1,2,3, Yi Zheng1,2, Enze Deng3,4

  • 1Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

Nucleic acids research
|February 10, 2026
PubMed
概括

针对BAF复合体,通过对其染色质进行压缩,以表观遗传方式使乙型肝炎病毒 (HBV) 的共闭圆形DNA (cccDNA) 沉默. 这种新的策略,使用像FHT-2344这样的抑制剂,为慢性HBV感染提供了潜在的功能治疗方法.

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