婴儿期维生素D补充:一个修订后的系统性审查
Francis B Mimouni1,2, Aviad Agam3, Iris Arad4,5
1The Department of Pediatrics, Leumit Health Services, and the Leumit Research Institute.
Current opinion in clinical nutrition and metabolic care
|February 10, 2026
概括
建议婴儿补充维生素D,以防止缺乏并支持骨健康. 风险群体可能需要更高的剂量或延长补充剂,但对非骨效益的证据仍在发展.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 婴儿维生素D补充对于骨发育至关重要.
- 最佳剂量和人群变异性仍然是正在进行的研究领域.
- 新出现的证据探讨了维生素D的非骨效应.
研究的目的:
- 系统地审查有关婴儿维生素D补充的最新证据.
- 评估最佳的剂量策略和人群变异性.
- 评估新出现的非皮肤效应和临床实践差距.
主要方法:
- 系统评估最近的随机试验和元分析.
- 专注于针对剂量,人口因素和非骨性结果的研究.
- 分析证据以将发现转化为政策和实践.
主要成果:
- 每天400 IU的维生素D在大多数健康婴儿中保持了足够的维生素D水平.
- 较高的剂量 (600-1200 IU) 可能是必要的风险婴儿.
- 关于非骨性 (免疫,呼吸) 益处的证据是不确定的;注意到异质性.
结论:
- 普遍支持婴儿维生素D补充剂,以预防缺乏并确保骨健康.
- 高剂量或婴儿后补充剂的益处是不确定的.
- 需要进一步研究剂量反应,长期安全性和系统性影响.
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