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Updated: Feb 11, 2026

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特定于性别的ALS遗传结构:女性保护作用的证据?

Maurizio Grassano1, Francesca Palumbo1, Gabriele Mora1

  • 1Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.

Annals of neurology
|February 10, 2026
PubMed
概括

患有肌缩侧面硬化症 (ALS) 的女性具有较高的罕见有害遗传变异负担,表明性别特异性遗传责任. 性别影响ALS基因的遗传风险不同,特别是TARDBP.

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