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科拉希斯皮达树叶提取物通过抗氧化剂调节在老鼠中减轻四化碳诱导的肝,,血液毒性

Njideka I Ani¹, Nnenna Ajagu², Kenneth O Okolo¹

¹Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Enugu State, Nigeria.

Environmental toxicology

|February 10, 2026

概括

科拉希斯皮达提取物可以保护大鼠免受四化碳 (CCl4) 诱导的肝脏,脏和血液损伤. 这项研究表明MECH.

科学领域:

药理学和毒理学药理学和毒理学
自然产品化学自然产品化学
生物化学生物化学

背景情况:

碳四化物 (CCl4) 是已知的全身毒性诱导剂,对肝脏,脏和血液造成重大损害.
氧化应激是CCl4引起的器官损伤的关键机制.
科拉希斯皮达 (Cola hispida) 是一种用于民族医学的植物,据报道具有抗氧化特性.

研究的目的:

在大鼠中研究可乐西 (MECH) 的甲醇提取物对CCl4诱导的全身毒性的保护作用.
评估MECH对氧化应激生物标志物,肝脏和脏功能以及血液学参数的影响.
评估CCl4暴露和MECH治疗后器官的组织病理变化.

主要方法:

鼠被分为六组,包括对照组,只有CCl4,以及用不同剂量的MECH联合治疗的组.
CCl4是通过腹腔内给药以诱导毒性.
通过生物化学测定 (肝/功能,氧化应激标志物),血液学分析和组织病理学评估保护作用.

主要成果:

CCl4的使用显著增加了肝脏和脏损伤标志物,氧化应激 (MDA升高) 和血液学障碍.
同时服用MECH的剂量依赖性逆转了这些CCl4诱导的变化.
MECH治疗恢复了抗氧化酶水平 (SOD,CAT,GSH,GPx) 并减少了组织病理组织损伤.

结论:

科拉希斯皮达的甲醇提取物 (MECH) 在老鼠中显示出显著的保护作用,防止CCl4诱导的肝和血液毒性.
MECH主要通过抗氧化和抗炎机制来发挥其保护作用.
这些发现支持科拉西皮达在民族药理学上用于管理与氧化应激相关的多器官毒性.

关键词:

科拉是他的第一个.CCl4 CCl4 CCl4 CCl4 CCl4 CCl4 CCl4 CCl4 CCl4 CCl4 抗氧化剂活性抗氧化剂活性血液学参数血液学参数肝毒性 - 肝毒性氧化应激是一种氧化应激.

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