鉴定了一种具有免疫调节活性的南极 (Euphausia superba)
Ruoting Hou1,2, Zhipeng Zheng1,2, Jinge Shao1,2
1Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China. jiamiaohu@fafu.edu.cn.
Food & function
|February 10, 2026
概括
南极的片显示出强大的免疫增强效应. 一种特定的,RDWPEGRG,增强了巨细胞的功能,并恢复了斑马鱼的免疫力,这表明它具有提高免疫力的食物和营养药物的潜力.
科学领域:
- 海洋生物技术 海洋生物技术
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 南极 (Euphausia superba) 是生物活性的来源.
- 生物活性可能具有免疫调节性质.
- 评估水解剂对免疫增强有兴趣.
研究的目的:
- 为了研究南极的免疫调节作用,南极的酶化水解剂.
- 为了分离和描述负责免疫增强的生物活性.
- 为了阐明作用机制,并在体内验证疗效.
主要方法:
- 南极的酶性水解. 南极的酶性水解.
- 使用超过和染色学进行分化.
- 在体外测定使用RAW264.7巨细胞 (增殖,细胞,NO分泌).
- 使用HPLC-MS/MS进行标识.
- 对基因表达的分析 (IL-6,CCL2,CCL5).
- 线粒体呼吸试验.线粒体呼吸试验.
- 在体内研究使用斑马鱼免疫抑制模型.
主要成果:
- 中性蛋白酶水解酶的活性最高,促进巨细胞的增殖.
- 孤立的RDWPEGRG显著增强了巨细胞的增殖,细胞和氧化分泌.
- RDWPEGRG上调了与免疫相关的基因 (IL-6,CCL2,CCL5) 和增加了氧气消耗率.
- 在免疫抑制的斑马鱼中,RDWPEGRG通过增强巨细胞活动和使中性粒细胞数量正常化,恢复了免疫能力.
结论:
- 来自南极水解的RDWPEGRG是一种强大的免疫刺激.
- RDWPEGRG在体外和体内表现出显著的免疫调节作用.
- 这种具有作为免疫增强食品和营养药物应用的功能成分的潜力.
相关概念视频
Peptide Identification Using Tandem Mass Spectrometry
8.6K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
8.6K
Peptide Bonds
83.4K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.4K
Methods of Classification and Identification
1.3K
Bacterial identification relies on a diverse array of techniques to classify and understand microorganisms, each tailored to uncover specific characteristics. Traditional morphological approaches, while still valuable, are limited for closely related or structurally simple organisms. Modern methods integrate biochemical, serological, genetic, and advanced molecular tools to achieve greater accuracy.Morphological and Biochemical TechniquesMorphological characteristics, such as cell shape and...
1.3K
Co-activators and Co-repressors
8.7K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.7K
tRNA Activation
23.1K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
23.1K
Activation Energy
87.0K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
87.0K


