消化道粘膜巨细胞密度和降粒度在胃食道逆流性疾病中增加
1Wingate Institute of Neurogastroenterology, Blizard Institute, the Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
American journal of physiology. Gastrointestinal and liver physiology
|February 10, 2026
概括
乳腺细胞在患有胃食道逆流病 (GERD) 的患者的食道内膜中更为众多和活跃. 这种增加的巨细胞活动可能会导致GERD症状和炎症,这表明潜在的新治疗点.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 胃食道逆流性疾病 (GERD) 涉及内脏疼痛和食道炎症.
- 巨细胞失调与肠-大脑相互作用障碍有关,但在GERD中未得到充分研究.
- 鉴定GERD中巨细胞的存在和活性对于了解疾病机制至关重要.
研究的目的:
- 调查GERD患者的食道粘膜中的乳腺细胞局部化和脱粒化.
- 为了比较健康对照和GERD亚组 (FH,NERD,ERD) 之间的巨细胞特征.
主要方法:
- 从健康对照组 (HC) 和GERD患者 (FH,NERD,ERD) 的食道活检进行了分析.
- 免疫组织化学被用来检测酸酶的表达,识别巨细胞.
- 评估了乳腺细胞局部化 (皮内皮质,乳头皮) 和脱粒状态.
主要成果:
- 与HC相比,ERD患者在食道乳头和上皮中表现出较高的杆细胞密度.
- 在FH和ERD中观察到更高的脱粒化内皮质巨细胞密度.
- NERD和ERD在乳头中表现出脱粒性巨细胞的增加;FH显示了内皮质巨细胞和症状得分之间的相关性.
结论:
- 乳腺细胞在ERD中更丰富,在FH,NERD和ERD中更活跃.
- 增加的巨细胞活动可能会导致食道炎症,障碍物问题和GERD中的过敏性.
- 粘膜巨细胞代表了GERD管理的潜在治疗点.
相关概念视频
Esophageal Varices-I: Introduction
1.5K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.5K
Esophageal Perforation-I: Introduction
619
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
619
Esophageal Strictures-I: Introduction
908
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
908
Esophageal Strictures-II: Clinical Features and Management
694
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
694
Esophageal Perforation-II: Clinical Manifestations and Management
746
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
746
Esophageal Varices-II: Clinical Features and Management
603
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
603


