一个可穿戴的3D打印空心微针装置,用于压力驱动的间歇性流体收集和测试
Nedim Hacıosmanoğlu1,2, Emre Ece1,2, Fatih Inci1,2
1UNAM-National Nanotechnology Research Center, Bilkent University, 06800, Ankara, Turkey. finci@bilkent.edu.tr.
Lab on a chip
|February 10, 2026
概括
这项研究介绍了μHolloSense,这是一个3D打印的微针装置,用于最小侵入性间歇性液体 (ISF) 收集. 这种可穿戴设备可以实现经济高效的生物标志物分析,为个性化健康监测提供了一种新方法.
科学领域:
- 生物医学工程:开发用于生物传感的新型微针装置.
- 材料科学:对医疗器械进行立体石版 (SLA) 3D 打印的应用.
- 分析化学:利用间歇液体进行微创生物标志物检测.
背景情况:
- 间歇性流体 (ISF) 是一种可访问的生物流体储,用于生物标志物分析.
- 传统的ISF收集方法具有侵入性.
- 微针 (MN) 技术为ISF采样提供了一种最小侵入性的替代方案.
研究的目的:
- 设计和制造用于ISF收集的可穿戴空心微针 (MN) 装置.
- 为了整合负压辅助采集和侧流量测试 (LFA) 的兼容性.
- 通过皮肤模拟平台和实体实验来评估MN设备的性能.
主要方法:
- 基于单步立体石版 (SLA) 的3D打印制造空心MN设备 (μHolloSense).
- 开发一个以3D打印的,基于阿加罗斯的皮肤仿真平台,用于标准化的评估.
- 在小鼠皮肤上的ex vivo实验以验证ISF提取和LFA测试中的性能.
主要成果:
- μHolloSense展示了成功的ISF采集,其尖端直径和高度得到了改进.
- 该设备显示出强大的机械性能和有效的IgG检测在各种度.
- 活体实验显示,ISF含量高达6μL,其度与生理蛋白质有关.
结论:
- 该研究提出了一个统一的战略,用于3D打印的空心MN系统,用于基于ISF的生物分子分析.
- μHolloSense为生物标志物采样提供了一种具有成本效益 (每台设备1美元) 和最少侵入性的解决方案.
- 这个平台有潜力在个性化健康中进行持续监测和护理点诊断.
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