乳制品摄入量和美国男性和女性发生炎症性肠病的风险
Alexa N Sasson1, Kevin Casey2,3, Emily W Lopes2,3
1Division of Gastroenterology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Clinical and translational gastroenterology
|February 10, 2026
概括
更高的乳制品摄入量,特别是酸奶,可能会降低性结肠炎 (UC) 的风险. 这项大型研究发现,乳制品消费与UC发病率之间存在潜在的反向关联,但并非克罗恩病.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 自免疫性疾病,包括炎症性肠病 (IBD),是严重的健康问题.
- 饮食因素,如乳制品消费在IBD发展中的作用需要进一步研究.
研究的目的:
- 研究乳制品摄入量与发展炎症性肠病 (IBD) 风险之间的关联.
- 探索特定的乳制品成分及其与IBD亚型,克罗恩病 (CD) 和性结肠炎 (UC) 的关系.
主要方法:
- 一项前性队列研究,涉及护士健康研究 (NHS),NHSII和卫生专业人员随访研究 (HPFS) 的197763名参与者.
- 乳制品摄入量数据是通过经过验证的食物频率调查问卷收集的,分为五分之一的分析.
- 考克斯的比例危险模型用于计算调整的危险比率 (aHR) 和95%置信区间 (CI).
主要成果:
- 在整体乳制品摄入量和性结肠炎 (UC) 风险之间观察到一个反向关联 (aHR 0.72).
- 酸奶消费显示出与UC风险降低的最强相关性 (HR 0.70).
- 在乳制品摄入量和克罗恩病 (CD) 风险之间没有发现一致的关联.
结论:
- 在基线乳制品摄入量,特别是酸奶和患性结肠炎 (UC) 的风险之间存在一种暗示性的反向关联.
- 需要进一步的研究来证实这些发现,并阐明潜在的机制.
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