作为从未吸烟者早期肺腺癌复发的预后标记,体内副本数的变化是复发的预后标记
Stijn Vanstraelen1, Allison Reiner2, Kay See Tan2
1Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
早期肺腺癌的体质副本数变异 (CNVs) 预测复发. 低CNV瘤显示出良好的预后,而中等和高CNV瘤表明,在从未吸烟者中复发的风险更高.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 癌症研究 癌症研究
背景情况:
- 与吸烟者相比,从不吸烟者的肺癌具有明显的基因组特征.
- 身体副本数变异 (CNVs) 与晚期癌症的不良结果有关,但它们在早期肺腺癌中的作用尚不清楚.
研究的目的:
- 在从不吸烟者中调查NVs在早期肺腺癌的预后意义.
- 为了识别不同的 CNV 概况及其与瘤复发的关联.
主要方法:
- 进行了对210名治疗前未吸烟的早期肺腺癌患者的队列进行CNV的层次分类.
- 根据患者的 CNV 负担,患者被分为低,中等和高 CNV 组.
- 在不同CNV组中分析了复发率和5年累积发病率.
主要成果:
- 确定了三个不同的CNV组:低CNV (41%),中等CNV (36%) 和高CNV (23%).
- 五年累计复发发病率在低CNV组 (14%) 与中度CNV (31%) 和高CNV (48%) 组相比显著较低 (p=.004).
- 调整后的复发危险比为2.30对于中度CNV和2.65对于高CNV,这表明CNV状态是复发的独立预测因素.
结论:
- CNV状态是从不吸烟者中早期肺腺癌复发的独立预测因素.
- 低CNV瘤与最有利的预后有关,而中度和高CNV瘤表明复发风险更高.
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