在格陵兰人和丹麦人中,甲状腺对棕色脂肪组织冷激活的反应
Mette Motzfeldt Jensen1,2, Charlotte Elberling Almasi1,3, Stine Linding Andersen1,4
1Department of Clinical Medicine, Aalborg University, Aalborg 9000, Denmark.
European journal of endocrinology
|February 10, 2026
概括
暴露于寒冷会影响甲状腺激素,影响棕色脂肪组织 (BAT) 热生成. 适应寒冷的个体表现出明显的甲状腺反应,表明对寒冷环境的生理准备.
科学领域:
- 内分泌学 在内分泌学.
- 人体生理学 人体生理学
- 热生成是一种热生成.
背景情况:
- 棕色脂肪组织 (BAT) 热生成是由交感神经系统和甲状腺激素调节的,这些激素可调节脱蛋白1.
- 在习惯性暴露于寒冷的人群中研究甲状腺激素对寒冷的反应,可以了解非发的热生成.
研究的目的:
- 检查格陵兰人和丹麦人在急性感冒暴露时的甲状腺激素和甲状腺球蛋白反应.
- 为了将甲状腺激素水平和BAT活动与寒冷适应相关联.
主要方法:
- 一项涉及21名参与者 (11名格陵兰人,10名丹麦人) 的交叉研究,暴露在冷却和热舒适条件下.
- 使用正子发射断层扫描/计算机断层扫描 ([18F]FDG PET/CT) 扫描来评估BAT活动.
- 序列血液样本测量了铁氨酸 (TSH),总三铁氨酸 (TT3),总铁氨酸 (TT4) 和铁球蛋白 (Tg).
主要成果:
- 冷却在两组中都增加了TSH和TT3水平,格陵兰人与丹麦人相比显示出更低的TSH和更高的基线TT3.
- 格陵兰人对冷却的TT3反应减弱,但T3/T4比率始终较高,表明甲状腺激素激活增强.
- 甲状腺蛋白 (Tg) 水平在具有较低BAT体积的个体中较高,这表明甲状腺功能和BAT质量之间存在联系.
结论:
- 观察到明显的甲状腺激素和甲状腺蛋白对冷却的反应,与BAT活性相关.
- 研究结果表明,适应寒冷的个体,无论其来源如何,都对寒冷暴露有生理准备.
- 甲状腺激素在不发的热生成和适应寒冷环境中起着至关重要的作用.
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