创建3D参考剂量计数据集,以采用永久植入前列腺骨干治疗的基于模型的剂量计算
Fatemeh Akbari1, Vasiliki Peppa2, Samuel Ouellet1,3,4
1Carleton Laboratory for Radiotherapy Physics, Physics Department, Carleton University, Ottawa, Ontario, Canada.
Medical physics
|February 10, 2026
概括
这项研究创建了测试案例和数据集,以验证前列腺骨干治疗的基于模型的剂量计算算法 (MBDCAs),提高癌症治疗中的剂量准确性.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 计算剂量计计算剂量计.
背景情况:
- 标准的TG-43形式主义在前列腺癌治疗中对准确的剂量评估有局限性.
- AAPM,ESTRO和ABG的建议强调需要改进剂量计算方法.
- 基于模型的剂量计算算法 (MBDCAs) 提供了提高准确性的潜力.
研究的目的:
- 创建和验证一套全面的测试案例MBDCAs在永久植入前列腺支臂疗法.
- 为MBDCAs开发3D参考剂量测量数据集,解决TG-43的局限性.
- 为了与186联合工作组改善剂量评估的建议保持一致.
主要方法:
- 使用I-125 OncoSeed 6711与三个蒙特卡洛代码 (EGSnrc,MCNP,PenRed) 模拟了六个测试场景.
- 从CT图像开发了一个虚拟患者模型,包括有和没有化的病例.
- 使用本地和全球指标进行验证的剂量比较,以eb_gui作为参考.
主要成果:
- 在测试案例中,蒙特卡洛代码协议在~3.0% (本地) 和0.01% (全球) 之间.
- 验证的试验案例范围从简单的单种子设置到复杂的58种子患者模型.
- 全面的剂量测量数据集公开可用于MBDCA的开发和验证.
结论:
- 开发的测试案例对于MBDCA的开发,验证和调试至关重要.
- 这些资源可以提高复杂的前列腺支臂疗法植入物的剂量测量精度.
- 这项研究为未来关于支臂治疗剂量计算的研究提供了一个平台.
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