在患有转移性割抵抗性前列腺癌的患者中首次对YF2进行人体评估
Xiaoai Wu1, Yongzhao Xiang1, Michael R Zalutsky2
1Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
European journal of nuclear medicine and molecular imaging
|February 10, 2026
概括
新型的α粒子治疗剂 [211At]YF2安全地给转移性割抵抗性前列腺癌患者. 这项研究证实了转移性病变的清晰划分和有利的剂量测量,支持了 [211At]YF2.2 的进一步临床开发.
科学领域:
- 核医学和放射性药物治疗
- 瘤学和前列腺癌研究
- 医学成像和剂量测量
背景情况:
- 转移性割抵抗性前列腺癌 (mCRPC) 仍然是一个重大的临床挑战.
- 前列腺特异性膜抗原 (PSMA) 是mCRPC成像和治疗的验证标.
- 阿尔法粒子发射器由于其高线性能量转移,提供了强大的治疗潜力.
研究的目的:
- 在0期微剂量研究中,评估阿尔法粒子发射PSMA抑制剂 [211At]YF2的安全性,生物分布和剂量.
- 评估使用211At衰变的X射线用于在mCRPC患者中成像转移性病变的可行性.
主要方法:
- 最初的生物分布研究是在CD-1小鼠中进行的.
- 三名患有PSMA阳性转移的mCRPC患者接受了静脉 [211At]YF2 (29.6-44.4 MBq).
- 在不同的时间点进行全身平面成像和SPECT/CT扫描;使用Rapid 3D-RD软件评估安全性和剂量.
主要成果:
- [211At]YF2在患者中耐受良好,所有不良事件都是2级或更低的.
- 在脏,膀,唾液腺和甲状腺中观察到高的初始吸收,随后是快速清除.
- 转移性病变明显可视化,剂量计表明剂量为31.4mGy/MBq至最突出的转移,脏剂量为15.3mGy/MBq.
结论:
- [211At]YF2可以安全地给予mCRPC患者,使得转移性病变的清晰划分.
- 观察到的 [211At]YF2 的生物分布和剂量学概况有利于临床应用.
- 这些发现支持对mCRPC治疗的 [211At]YF2 的进一步临床开发.
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