在PICU的微生物特征和风险因素与淡水溺水相关的肺炎
Nan Zhang1, Xiaojing Zhang2,3, Yuxin Guo2
1Department of Pediatric Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' health and Diseases, 3333 Binsheng Road, Binjiang District, Hangzhou, Zhejiang, China.
European journal of pediatrics
|February 10, 2026
概括
儿童重症监护室 (PICU) 的儿童患有溺水相关肺炎 (DAP) 是常见的,但不会增加死亡率. 黄金葡萄球菌 (Staphylococcus aureus) 是一个关键的病原体,需要针对性的抗生素治疗.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 传染病 传染病 传染病
- 复苏科学是一种复苏科学.
背景情况:
- 溺水是儿童重症监护室 (PICU) 入院的重要原因之一.
- 溺水相关性肺炎 (DAP) 是一种常见的并发症,具有诊断挑战,并且经常需要经验广泛的抗生素.
研究的目的:
- 研究儿童溺水患者DAP的临床特征,干预措施,微生物学和治疗.
- 分析这些因素与患者预后之间的相关性,包括死亡风险.
主要方法:
- 对141名入住PICU (2019-2024) 的儿童淡水溺水患者进行了回顾性研究.
- 队列分为DAP和非DAP组进行比较分析.
- 后勤回归用于识别出院后28天死亡率的风险因素.
主要成果:
- 在71名患者中发生了DAP;与非DAP患者相比,初始复苏时间没有显著差异.
- DAP组住院/PICU时间较长,但出院率较低 (18.31%与41.43%) 和出院后28天死亡率 (22.54%与47.14%).
- 黄金葡萄球菌和Mycoplasma pneumoniae是常见的病原体;组合疗法和linezolid的使用在DAP组中更高.
结论:
- DAP是儿童溺水幸存者的常见并发症,但与死亡率增加无关.
- 金黄色葡萄球菌是一种流行病原体,支持覆盖格兰阳性细菌的经验性抗生素策略.
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